Objective. Laparostomy can be applied in trauma, abdominal sepsis, intra-abdominal hypertension, or compartment syndrome.\nSystemic infections, especially if complicated by Candida, are associated with a high risk of mortality. Methods. This is a singlecentre\nretrospective case series of 47 cases admitted to our Department, which required laparostomy procedure; we analyzed the\ntype of surgery, temporary abdominal closure, duration of open abdomen, complications, SOFA score, mortality with Candida\ninfections, and empirical or targeted antifungal therapy. Results. We found that patients with Candida infection were related\nwith a statistically significant difference (p < 0 05) with a complication after OA closure, total complications, time elapsed after\nOA application, time spent on the first surgical OA application, type of temporary abdominal closure that is used, and duration\nof the open abdomen. The use of empirical and targeted antifungal therapy is related to the duration of open abdomen too.\nConclusions. Management of the OA is often burdened by sepsis or septic shock, especially when complicated by Candida\ninfection. Candida score is a validated tool to identify patients who can be treated empirically, but every situation must be\nconsidered on an individual basis.
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